[Dottorcomp] Insalate di Matematica - S. Tonali 12/03/2025

[Insalate Di Matematica]

Dear all,

We remind you *today*'s appointment of the series of seminars "Insalate di
Matematica".
Here are the details:

*Speaker*: *Sofia Tonali* (Università degli Studi di Pavia)

*Date and time*: *12th of March 2025, 4:30 pm (CET)*

*Title*: "Mathematical modeling of Multielectrode Arrays with Pluripotent
Stem Cell-Derived Cardiomyocytes"

*Abstract*: After their discovery, human-induced pluripotent stem
cell-derived cardiomyocytes (hiPSC-CMs) are transforming cardiac research,
offering patient-specific alternatives for studying heart physiology and
diseases. However, their electrical behavior differs from adult heart
cells, making mathematical modeling crucial for understanding their
properties.

        In this talk, a new in silico model, based on partial differential
equations, will be presented. This model simulates the electrical activity
of hiPSC-CMs and their interaction with microelectrode arrays (MEA), a
non-invasive tool that records extracellular signals. The model captures
key electrophysiological phenomena, from action potential propagation to
conduction velocity, bridging the gap between intracellular dynamics and
MEA recordings. Numerical results to illustrate the model in action and its
potential applications will also be presented.

*Keywords:* hiPSC-CMs & cardiac dynamics, Partial differential equations,
Bidomain model, Numerical simulations

*Information to attend in room 3014*
The seminar will take place in room 3014, at the building U5-Ratio,
Università degli Studi di Milano Bicocca.


*Information to attend online*
https://unimib.webex.com/unimib/j.php?MTID=m101728a0c0258813b6aa97783fb11fad
(password: insalate, 46725283 from phones)
<https://unimib.webex.com/unimib/j.php?MTID=m3c536ba5a33f71bb9d6a3bc9b00992ad>

For further information, please visit our website:
https://sites.google.com/view/insalate-di-matematica or contact us at
insalate.matematica a unimib.it. Find us also on our Instagram page:
https://www.instagram.com/insalate_di_matematica24/

The organizers: Anna Donadini, Julian Feuerpfeil, Marco Fusari,
Kirubell Haile, Paolo Malanchini, Ettore Marmo, Fabio Mastrogiacomo,
Claudia Nocita, Eleonora Sforza and Tommaso Toti.