[Dottorcomp] METaL Seminar: Sofia Botti, "Multiscale Modeling in Computational Cardiology: From Cells to Tissue Dynamics", April 23rd, 11:00-12:00, Aula Beltrami

[Siam Student Chapter]

Dear all,

We're pleased to invite you to our upcoming *METaL **Seminar **- Mathematics
& Engineering Talks And Lectures -* hosted by the SIAM Student Chapter of
Pavia in collaboration with the Compmech group at DICAr.

Here are the details of the Seminar*:*

   - *Speaker*: Sofia Botti - Researcher at MOX, Department of Mathematics,
   Politecnico di Milano.


   - *Title*:* Multiscale Modeling in Computational Cardiology: From Cells
   to Tissue Dynamics.*


   - *Where and when*: April 23rd, *11:00-12:00*, Aula Beltrami, Department
   of Mathematics, University of Pavia.


   - *Abstract: *Computational cardiology provides a mathematical framework
   for describing and simulating cardiac electrophysiology across multiple
   spatial and temporal scales. Starting from cellular models of ionic
   currents, continuum formulations enable the study of emergent electrical
   activity at the
   tissue level, giving rise to complex multiscale systems characterized by
   strong nonlinearities, heterogeneity, and coupling across scales. A
   particularly active application area is the modeling of human induced
   pluripotent stem cellderived cardiomyocytes (hiPSC-CMs), which are
   increasingly used in regenerative medicine and drug testing as
   experimentally accessible but highly variable cardiac models. This setting
   introduces additional mathematical challenges related to tissue
   heterogeneity, variability in cellular phenotypes, and the interpretation
   of indirect experimental measurements. Within this framework, different
   modeling paradigms are used to connect cellular dynamics with observable
   extracellular signals, highlighting how alternative mathematical
   formulations can lead to different quantitative and qualitative
   predictions. Numerical simulations play a central role in exploring how
   spatial organization, heterogeneity, and measurement processes influence
   the relationship between internal states and recorded data. Overall,
   computational cardiology emerges as a multiscale modeling discipline in
   which mathematical structure, numerical methods, and data interpretation
   interact to support both fundamental understanding and applied developments
   in regenerative medicine.


We look forward to your participation!
If you are not able to attend in presence, you can follow online using the
following link https://meet.google.com/iqb-hwyv-chm.

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Sincerely,

SIAM Chapter Organization Committee
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