<div dir="ltr"><div dir="ltr"><span style="color:rgb(0,0,0)">Dear all,</span><div dir="auto"><span style="color:rgb(0,0,0)"><br></span></div><div dir="auto"><span style="color:rgb(0,0,0)">For the <i>next appointment</i> of the series of seminars "Insalate di Matematica", <b>Sofia Tonali</b> (Università degli Studi di Pavia) will give a talk. </span></div><div dir="auto"><span style="color:rgb(0,0,0)">The speaker will deliver the talk <u>in presence</u> and the meeting will also be broadcasted <u>online</u> (see below for more information).</span></div><div dir="auto"><span style="color:rgb(0,0,0)"><br></span></div><div dir="auto"><span style="color:rgb(0,0,0)">Here the details:</span></div><div dir="auto"><span style="color:rgb(0,0,0)"><br></span></div><div dir="auto"><span style="color:rgb(0,0,0)"><u>Date and time</u>: <b>12th of March 2025, 4:30 pm (CET)</b></span></div><div dir="auto"><br></div><div dir="auto"><div dir="auto"><font color="#000000"><u>Title</u>: <span style="background-color:rgb(255,229,153)">"</span></font><span style="background-color:rgb(255,229,153)">Mathematical modeling of Multielectrode Arrays with Pluripotent Stem Cell-Derived Cardiomyocytes</span><font color="#000000"><span style="background-color:rgb(255,229,153)">"</span></font></div><div dir="auto"><font color="#000000"><span style="background-color:rgb(255,229,153)"><br></span></font></div><div dir="auto"><font color="#000000"><u>Abstract</u>:</font> After their discovery, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are transforming cardiac research, offering patient-specific alternatives for studying heart physiology and diseases. However, their electrical behavior differs from adult heart cells, making mathematical modeling crucial for understanding their properties.</div><br> In this talk, a new in silico model, based on partial differential equations, will be presented. This model simulates the electrical activity of hiPSC-CMs and their interaction with microelectrode arrays (MEA), a non-invasive tool that records extracellular signals. The model captures key electrophysiological phenomena, from action potential propagation to conduction velocity, bridging the gap between intracellular dynamics and MEA recordings. Numerical results to illustrate the model in action and its potential applications will also be presented.<div dir="auto"><br></div><div dir="auto"><font color="#000000"><u>Keywords:</u></font> hiPSC-CMs & cardiac dynamics, Partial differential equations, Bidomain model, Numerical simulations</div><div dir="auto"><br></div><div dir="auto"><div dir="auto"><u><b>Information to attend in room 3014</b></u></div><div dir="auto">The seminar will take place in room 3014, at the building U5-Ratio, Università degli Studi di Milano Bicocca.</div><div dir="auto"><br></div><div dir="auto"></div><div dir="auto"><u><b>Information to attend online<br></b></u></div><div dir="auto"><a href="https://unimib.webex.com/unimib/j.php?MTID=m101728a0c0258813b6aa97783fb11fad" target="_blank">https://unimib.webex.com/unimib/j.php?MTID=m101728a0c0258813b6aa97783fb11fad</a> (password: insalate, 46725283 from phones)<a href="https://unimib.webex.com/unimib/j.php?MTID=m101728a0c0258813b6aa97783fb11fad" target="_blank"></a></div><div dir="auto"><br></div><div dir="auto"><div dir="auto">You can find the poster of the event in the attachment. </div><div dir="auto">We are looking forward to seeing you! </div><div dir="auto"><br></div><div dir="auto"></div><div dir="auto">For further information, please visit our website: <a href="https://sites.google.com/view/insalate-di-matematica" rel="noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer" target="_blank">https://sites.google.com/view/insalate-di-matematica</a> or contact us at <a href="mailto:insalate.matematica@unimib.it" rel="noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer" target="_blank">insalate.matematica@unimib.it</a>. Find us also on our Instagram page: <a href="https://www.instagram.com/insalate_di_matematica24/" rel="noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer noreferrer" target="_blank">https://www.instagram.com/insalate_di_matematica24/</a></div><div dir="auto"><br></div><div dir="auto"><div dir="auto"><div dir="ltr"><div dir="auto"><div dir="auto"><div dir="auto"><div dir="auto"><div dir="auto"><font color="#000000">The organizers: Anna Donadini, Julian Feuerpfeil, Marco Fusari, Kirubell Haile, Paolo Malanchini, Ettore Marmo, Fabio Mastrogiacomo, Claudia Nocita, Eleonora Sforza and Tommaso Toti.</font></div></div></div></div></div></div></div></div></div></div></div></div>
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